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Road Trip to Tucson Arizona from Palm Springs California

Writer: Kathy Condon
Kathy Condon
Jun 6, 2025
6 min read

Mural of a woman playing guitar, surrounded by cacti and orange flowers. Text reads Rialto Theatre, Tucson AZ. Vibrant colors, serene mood.
One of the 200-plus murals in Tucson Arizona Photo by Kathy Condon

Tucson, Arizona, situated 116 miles southeast of Phoenix and 69 miles from the Mexican border, is the second-largest city in Arizona. It had been on my radar to visit ever since I moved to Southern California. I knew I could travel by car and make it a fun road trip with a friend.


Why you ask? I wanted to see Biosphere 2, a scientific laboratory where six people were enclosed in a glass dome-like structure for two years. And visit the town of Tubac, famous for the number of artists that have settled in the area, near Tumacacori National Historic Park.


The host has provided support for various aspects of the trip, including accommodations, activities, meals, and other services. However, the opinions expressed in this post are honest and reflect the author's genuine experience.


Preparing for the Road Trip

With the knowledge that we would be driving through the Sonoran Desert for much of our trip, we made sure to have plenty of water. It is well known that the stretch between Palm Springs and Phoenix (approximately a 3-hour drive) has long stretches with few services.


First Stop Quartzsite Arizona

California residents are well aware that gas prices are considerably lower in Arizona, so we made Quartzsite our first stop to stretch and refuel the car. It’s about a two-hour drive from Palm Springs. Especially during the winter months, you can find food trucks and local restaurants alerting travelers about their specialties.


Once we had a stretch, a snack, and a car refueled, we headed back to Highway 10—the only highway you stay on for the entire trip to Tucson. Our GPS showed us we would arrive at our destination at 3:00 p.m., perfect for checking into our bed and breakfast.


Next Stop Tucson Arizona

Highway 10 loops around Phoenix, so we never found ourselves stuck in traffic for the entire journey. Admittedly, the scenery between Phoenix and Tucson was more interesting, for it is evident that the population is starting to fill in the 110-mile gap between the cities.


Approaching the city, we noticed a few high-rise buildings, which we learned were housing for the University of Arizona students. Otherwise, the buildings were primarily two-story.

Tree on the left and light shining on the Armory Park Inn Inn in Tucson
Night Scene at the Armory Park Inn Photo by Kathy Condon

Arrival at our Bed and Breakfast

I usually make it a habit not to research too much about my housing accommodations, which organizations like Visit Tucson arrange. I prefer to let the place unfold and use my sense of observation as I check in and I am shown to my room. Thus, I didn’t know what to expect.


We pulled up in front of The Amory Park Inn, located in what appeared to be a regular residential area. Walking to the front door, we passed under an enormous tree that shaded the area. The door was locked. So, we pressed a buzzer, and very soon we were greeted by Amy, owner of the inn, wearing a peach-colored dress that perfectly highlighted her face, which beamed with a huge smile.


We walked in, and soon a sense of awe flooded over us, for before us there was a grand hallway with comfortable sitting areas on either side, and artwork gracing the long walls. In the far distance, a loft crossed the width of the room. There was a lightness about this place, and Amy's greeting made us feel immediately that we were in for a very special visit here.


Our first instincts were correct. This is one of the most special bed and breakfasts I have ever stayed at. Thus, I will be writing a full review of it, so stay tuned. You can't possibly go wrong staying here while exploring Tucson.


Impressions of Tucson

Hispanic Influence Everywhere

I should have figured it out, but it has more Hispanic influence than I expected. My traveling companion was from Mexico. She explained the terminology to me and how a particular experience reflected Mexican culture on multiple occasions. At museums, descriptions were in both English and Spanish.


The Old West Reflected in Culture

If you love everything Western, you are more than likely to find it here. We marveled at the ornate cowgirls' boots worn by many of the younger women. While we did not visit one, large dude ranches welcome guests.

Picture of gallery owners in their galley with art surrounding with them.
Galeria Mitotera Owners Mel and Melissa Dominquez Photo by Kathy Condon

Art is Everywhere

I heard that there are over 200 murals in Tucson. Everywhere you go, there is art displayed. We sat down with Galeria Mitotera owners, Mel and Melissa Dominquez, who ended up moving to Tucson from Los Angeles. She was born here, but her husband saw the wisdom of finding an area where his art could flourish. Not only did it flourish, but they have also purchased a large warehouse and will be expanding, making room available for artists to set up their studios.

The Mission San Xavier del Bac with two white towers.
Mission San Xavier del Back Photo by Kathy Condon

Tucson California Honors Its History

A visit to Tumacacori National Historical Park, on the Santa Cruz River Valley carefully watches over the remaining ruins of three Spanish colonial missions. While the footprints are there, precious artifacts have disappeared, but one gets the sense of the people who populated the area.


On the other hand, Mission San Xavier Del Bac's refurbished pristine exterior serves as a safe cocoon for the original stunning wood carvings, paintings, and statues. This Franciscan Mission, located on the Tohono O'Odham Indian Reservation, is often referred to as the "Sistine Chapel of North America."

Two tacos are covered with fresh ingredients and tomatoes.
Seis Restaurant Tacos Photo by Kathy Condon

Dining is Back to Its Roots

This may surprise you as much as it did me when I learned about it at the IMM Travel Conference in New York City last January. Tucson has been one of two cities named by UNESCO as a City of Gastronomy in the United States. The other one is San Antonio.


After digging, I found this definition: To become a UNESCO City of Gastronomy, a city must demonstrate a strong culinary identity and a vibrant gastronomy community, incorporating local know-how, traditional practices, and a commitment to sustainable food systems.


Digging further, I learned that considering this designation, Tucson is believed to be the first site within the current borders of the United States, 4,000 years ago, to have cultivated land.


It was always fun to pick up a menu, as I never knew which indigenous ingredient would serve as the main dish or condiment for the many culinary choices. Mexican Foodies will have a field day trying one of the many outstanding restaurants.


An abundance of Corporate Headquarters.

I certainly wasn’t expecting to discover the corporate headquarters for Caterpillar, Honeywell, Intuit, Raytheon Technologies (Missile & Defense Division), and IBM looming in the Tucson cityscape.

Scene on the Campus of the University of Arizona
University of Arizona Campus Photo by Kathy Condon

University of Arizona

The University of Arizona’s presence is everywhere. The campus is worth walking through, for art pops up in unexpected places. Additionally, the University of Arizona boasts the Center for Creative Photography and the University of Arizona Museum of Art. A large art complex also houses the theatre, adding dimension to the University's art offerings.


People Love Their City, and People Are So Friendly

Yes, many of the places I visited were set up by Visit Tucson. Still, it was when we talked to total strangers and saw their faces light up when we asked about their city—sometimes it was even hard to get away because of their enthusiasm, as they shared information about a city that appears to be going through an awakening.


More to Come About Tucson

Notice that I mentioned at the beginning of this article that I was excited about Biosphere 2 and Tubac, and I haven’t even written about it yet, yet I’m already up to 1100 words. You can tell that my enthusiasm for my visit to Tucson is abundant. A friend said, “Kathy, I haven’t heard you so eager to return to a place in a long time. “I will be writing more about Tucson and will link articles on it that may be posted in other publications.


As summer approaches, Tucson will be hot, but I encourage you to add it to your list of places to visit in the future. Numerous airlines offer flights from Palm Springs to Tucson, with most flights making a stop in Phoenix. I'm glad I took a road trip there, and if you have time, I highly encourage you to do the same. Maybe even break up the trip in Phoenix.


In the meantime, I trust that my enthusiasm for this sometimes-overlooked city has caught your attention. Stay tuned for my adventures at the Biosphere 2 and Tubac, and more details about the terrific Amory Park Inn as your destination from which to explore.

Kathy Condon in white shirt wearing large gold beads.
Kathy Condon Journalist and Award-Winning Author

Kathy Condon is a travel writer and award-winning author. Her niche is in luxury experiences, hidden delights, and communities that live in the shadows of others.   

760-902-3094              www.PalmSpringsInsiderGuide.com   kathy@kathycondon.net

 

 

24 Comments

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ameliaroy
4 days ago
Rated 5 out of 5 stars.

I really enjoyed reading about this road trip! Tucson sounds like such a hidden gem, and I love how you highlighted more than just the usual tourist attractions. The colorful murals, local art galleries, historic missions, and delicious regional food all sound like wonderful reasons to visit. I especially liked reading about the stop in Quartzsite and your experience at the Armory Park Inn. It's always nice when a trip includes unexpected discoveries and friendly people along the way. The reminder to carry plenty of water while driving through the Sonoran Desert is also very practical. Even on busy days with things like Qualitative Research Assignments Help to take care of, reading about adventures like this makes me want to…

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ameliaroy
4 days ago
Rated 5 out of 5 stars.

What a lovely travel experience! I really enjoyed reading about the journey from Palm Springs to Tucson, especially the stops along the way and the little details that make a road trip memorable. Tucson sounds like such an interesting place, with its colorful murals, rich history, beautiful architecture, and amazing food culture. I would especially love to explore the local art galleries and visit Mission San Xavier del Bac. The tip about carrying plenty of water while driving through the desert is also really helpful for anyone planning a similar trip. Even with busy days and tasks like Qualitative Research Assignments Help, reading about beautiful destinations like this makes me want to plan my next getaway. Thanks for sharing such…

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Guest
6 days ago

Tucson sounds like a wonderful place to explore! I especially enjoyed reading about Mission San Xavier del Bac, the vibrant street murals, and the city’s unique blend of history, culture, and food. The advice about carrying plenty of water for the desert drive is also helpful for anyone planning this route. Your enthusiasm makes me want to add Tucson and its surrounding attractions to my travel list. Thanks for sharing your experience! Yes Construction LLC

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Guest
6 days ago

What a lovely road trip guide! Tucson sounds like a fantastic destination, especially with its colorful murals, historic missions, local art galleries, and delicious regional cuisine. I also enjoyed the tips about preparing for the desert drive and stopping in Quartzsite along the way. Your description of the welcoming bed and breakfast makes the trip even more appealing. Definitely a great read for anyone looking for a memorable Arizona adventure! Noblesville Plumbers

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Guest
Oct 26

What a wonderful road trip guide! I enjoyed how you captured Tucson’s vibrant murals, rich cultural heritage, welcoming atmosphere, and incredible food scene, making it sound like a destination worth exploring beyond the usual tourist stops. The tips about preparing for the desert drive and stopping along the way are especially helpful for travelers planning their own adventure. For keeping renovation projects and task lists organized back home, Construction To-Do List Software is also worth checking out.

Make the backlink feel more naturalKeep the comment focused on travel

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